CATH Domain 1v3vA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Prostaglandin reductase 2

Enzyme Information

1.3.1.-	With NAD(+) or NADP(+) as acceptor. based on mapping to UniProt Q9EQZ5
1.3.1.74	2-alkenal reductase (NAD(P)(+)). based on mapping to UniProt Q9EQZ5 A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H. -!- Highly specific for 4-hydroxynon-2-enal and non-2-enal. -!- Alk-2-enals of shorter chain have lower affinities. -!- Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one. -!- Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. -!- Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
1.3.1.48	15-oxoprostaglandin 13-reductase. based on mapping to UniProt Q9EQZ5 11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H. -!- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. -!- The enzyme from placenta is specific for NAD(+).

UniProtKB Entries (1)

PTGR1_CAVPO

Cavia porcellus

Prostaglandin reductase 1

PDB Structure

PDB	1V3V
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop Hori, T., Yokomizo, T., Ago, H., Sugahara, M., Ueno, G., Yamamoto, M., Kumasaka, T., Shimizu, T., Miyano, M. J.Biol.Chem.