1 keywords

CATH Domain 1uxjA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.110 L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homologous Superfamily 3.90.110.10 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family Malate dehydrogenase

Enzyme Information

1.1.1.37
Malate dehydrogenase.
based on mapping to UniProt P80040
(S)-malate + NAD(+) = oxaloacetate + NADH.
-!- Also oxidizes some other 2-hydroxydicarboxylic acids.

UniProtKB Entries (1)

P80040
MDH_CHLAA
Chloroflexus aurantiacus J-10-fl
Malate dehydrogenase

PDB Structure

PDB 1UXJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Large Improvement in the Thermal Stability of a Tetrameric Malate Dehydrogenase by Single Point Mutations at the Dimer-Dimer Interface.
Bjork, A., Dalhus, B., Mantzilas, D., Sirevag, R., Eijsink, V.G.H.
J.Mol.Biol.