CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.420 | Peroxidase; domain 2 |
|
1.10.420.10 | Peroxidase, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Peroxidase, domain 2 |
| Functional Family | Catalase-peroxidase |
Enzyme Information
| 1.11.1.21 |
Catalase peroxidase.
based on mapping to UniProt P13029
(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.
|
UniProtKB Entries (1)
| P13029 |
KATG_ECOLI
Escherichia coli K-12
Catalase-peroxidase
|
PDB Structure
| PDB | 1U2L |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of the C-terminal domain of the catalase-peroxidase KatG from Escherichia coli.
Acta Crystallogr.,Sect.D
|
