CATH Domain 1u2eB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase

Enzyme Information

3.7.1.14

2-hydroxy-6-oxonona-2,4-dienedioate hydrolase.

based on mapping to UniProt P77044

(1) (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H(2)O = (2Z)-2- hydroxypenta-2,4-dienoate + succinate. (2) (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H(2)O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate.

-!- This enzyme catalyzes a step in a pathway of phenylpropanoid compounds degradation. -!- The first step of the enzyme mechanism involves a reversible keto- enol tautomerization. -!- Formerly EC 3.7.1.n1.

UniProtKB Entries (1)

P77044

MHPC_ECOLI

Escherichia coli K-12

2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase

PDB Structure

PDB	1U2E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The Structure of the C-C Bond Hydrolase MhpC Provides Insights into its Catalytic Mechanism Dunn, G., Montgomery, M.G., Mohammed, F., Coker, A., Cooper, J.B., Robertson, T., Garcia, J.-L., Bugg, T.D.H., Wood, S.P. J.Mol.Biol.