CATH Domain 1tveB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.360	Dihydrodipicolinate Reductase; domain 2
	3.30.360.10	Dihydrodipicolinate Reductase; domain 2

Domain Context

CATH Clusters

Superfamily	Dihydrodipicolinate Reductase; domain 2
Functional Family	Bifunctional aspartokinase/homoserine dehydrogenase

Enzyme Information

1.1.1.3

Homoserine dehydrogenase.

based on mapping to UniProt P31116

L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H.

-!- The enzyme from Saccharomyces cerevisiae acts most rapidly with NAD(+); the Neurospora enzyme with NADP(+). -!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 2.7.2.4.

UniProtKB Entries (1)

P31116

DHOM_YEAST

Saccharomyces cerevisiae S288C

Homoserine dehydrogenase

PDB Structure

PDB	1TVE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	New phenolic inhibitors of yeast homoserine dehydrogenase Ejim, L., Mirza, I.A., Capone, C., Nazi, I., Jenkins, S., Chee, G.L., Berghuis, A.M., Wright, G.D. Bioorg.Med.Chem.