CATH Domain 1tt8A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1410	Chorismate lyase
	3.40.1410.10	Chorismate lyase-like

Domain Context

CATH Clusters

Superfamily	Chorismate lyase-like
Functional Family	Chorismate pyruvate-lyase

Enzyme Information

4.1.3.40

Chorismate lyase.

based on mapping to UniProt P26602

Chorismate = 4-hydroxybenzoate + pyruvate.

-!- Catalyzes the first step in the biosynthesis of ubiquinone in Escherichia coli and other Gram-negative bacteria. -!- The yeast Saccharomyces cerevisiae can synthesize ubiquinone from either chorismate or tyrosine.

UniProtKB Entries (1)

P26602

UBIC_ECOLI

Escherichia coli K-12

Chorismate pyruvate-lyase

PDB Structure

PDB	1TT8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural analysis of ligand binding and catalysis in chorismate lyase. Smith, N., Roitberg, A.E., Rivera, E., Howard, A., Holden, M.J., Mayhew, M., Kaistha, S., Gallagher, D.T. Arch.Biochem.Biophys.