CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.132 | Topoisomerase I; Chain A, domain 4 |
|
1.10.132.10 |
Domain Context
CATH Clusters
| Superfamily | 1.10.132.10 |
| Functional Family | DNA topoisomerase I |
Enzyme Information
| 5.6.2.2 |
DNA topoisomerase.
based on mapping to UniProt P11387
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.
|
UniProtKB Entries (1)
| P11387 |
TOP1_HUMAN
Homo sapiens
DNA topoisomerase 1
|
PDB Structure
| PDB | 1TL8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Spodoptera |
| Primary Citation |
Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex As Determined by X-ray Crystallographic Analysis
J.Med.Chem.
|