CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.150 | DNA polymerase; domain 1 |
|
1.10.150.20 | 5' to 3' exonuclease, C-terminal subdomain |
Domain Context
CATH Clusters
| Superfamily | 5' to 3' exonuclease, C-terminal subdomain |
| Functional Family |
Enzyme Information
| 3.1.11.- |
Exodeoxyribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P00581
|
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt P00581
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
UniProtKB Entries (2)
| P0AA25 |
THIO_ECOLI
Escherichia coli K-12
Thioredoxin 1
|
| P00581 |
DPOL_BPT7
Enterobacteria phage T7
DNA-directed DNA polymerase
|
PDB Structure
| PDB | 1TK8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Embo J.
|
