CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P00471
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P00471
TYSY_BPT4
Escherichia virus T4
Thymidylate synthase

PDB Structure

PDB 1TIS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex.
Finer-Moore, J.S., Maley, G.F., Maley, F., Montfort, W.R., Stroud, R.M.
Biochemistry