CATH Classification

Domain Context

CATH Clusters

Superfamily Rhodanese-like domain
Functional Family Dual-specificity phosphatase CDC25

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q8GY31
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
1.20.4.1
Arsenate reductase (glutaredoxin).
based on mapping to UniProt Q8GY31
Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O.
-!- A molybdoenzyme. -!- The enzyme is part of a system for detoxifying arsenate. -!- Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds (cf. EC 1.20.4.4). -!- Formerly EC 1.97.1.5.

UniProtKB Entries (1)

Q8GY31
CDC25_ARATH
Arabidopsis thaliana
Dual specificity phosphatase Cdc25

PDB Structure

PDB 1T3K
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
A small CDC25 dual-specificity tyrosine-phosphatase isoform in Arabidopsis thaliana.
Landrieu, I., Da Costa, M., De Veylder, L., Dewitte, F., Vandepoele, K., Hassan, S., Wieruszeski, J.M., Faure, J.D., Van Montagu, M., Inze, D., Lippens, G.
Proc.Natl.Acad.Sci.Usa