CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.4100 | 2-methylcitrate dehydratase PrpD |
|
1.10.4100.10 | 2-methylcitrate dehydratase PrpD |
Domain Context
CATH Clusters
| Superfamily | 2-methylcitrate dehydratase PrpD |
| Functional Family | 2-methylcitrate dehydratase |
Enzyme Information
| 4.2.1.3 |
Aconitate hydratase.
based on mapping to UniProt P77243
Citrate = isocitrate.
-!- Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. -!- The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. -!- Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate. -!- Formerly EC 4.2.1.4.
|
| 4.2.1.79 |
2-methylcitrate dehydratase.
based on mapping to UniProt P77243
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3- tricarboxylate + H(2)O.
-!- Specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)- methylcitrate. -!- Can also use cis-aconitate as a substrate but more slowly. -!- Both this enzyme and EC 4.2.1.3 are required to complete the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate.
|
UniProtKB Entries (1)
| P77243 |
PRPD_ECOLI
Escherichia coli K-12
2-methylcitrate dehydratase
|
PDB Structure
| PDB | 1SZQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of 2-methylcitrate dehydratase
To be Published
|