CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | 2-isopropylmalate synthase |
Enzyme Information
| 2.3.3.13 |
2-isopropylmalate synthase.
based on mapping to UniProt P9WQB3
Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O = (2S)-2-isopropylmalate + CoA.
-!- Formerly EC 4.1.3.12.
|
UniProtKB Entries (1)
| P9WQB3 |
LEU1_MYCTU
Mycobacterium tuberculosis H37Rv
2-isopropylmalate synthase
|
PDB Structure
| PDB | 1SR9 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis
Proc.Natl.Acad.Sci.USA
|
