CATH Domain 1slyA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1240	Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1
	1.10.1240.20	Lytic transglycosylase, superhelical linker domain

Domain Context

CATH Clusters

Superfamily	Lytic transglycosylase, superhelical linker domain
Functional Family	Soluble lytic murein transglycosylase

Enzyme Information

4.2.2.n1

Peptidoglycan lytic exotransglycosylase.

based on mapping to UniProt P0AGC3

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.

UniProtKB Entries (1)

P0AGC3

SLT_ECOLI

Escherichia coli K-12

Soluble lytic murein transglycosylase

PDB Structure

PDB	1SLY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of the 70-kDa soluble lytic transglycosylase complexed with bulgecin A. Implications for the enzymatic mechanism. Thunnissen, A.M., Rozeboom, H.J., Kalk, K.H., Dijkstra, B.W. Biochemistry