CATH Domain 1sczA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.559	Chloramphenicol Acetyltransferase
	3.30.559.10	Chloramphenicol acetyltransferase-like domain

Domain Context

CATH Clusters

Superfamily	Chloramphenicol acetyltransferase-like domain
Functional Family	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex

Enzyme Information

2.3.1.61

Dihydrolipoyllysine-residue succinyltransferase.

based on mapping to UniProt P0AFG6

Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)- (S-succinyldihydrolipoyl)lysine.

-!- A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2 and EC 1.8.1.4. -!- The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalyzed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A.

UniProtKB Entries (1)

P0AFG6

ODO2_ECOLI

Escherichia coli K-12

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex

PDB Structure

PDB	1SCZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Improved structural model for the catalytic domain of E.coli dihydrolipoamide succinyltransferase Schormann, N., Symersky, J., Carson, M., Luo, M., Tsao, J., Johnson, D., Huang, W.-Y., Pruett, P., Lin, G., Li, S., Qiu, S., Arabashi, A., Bunzel, B., Luo, D., Nagy, L., Gray, R., Luan, C.-H., Zhang, Z., Lu, S., DeLucas, L. To be Published