CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.2340 | Pseudouridine synthase |
|
3.30.2340.10 | TruD, insertion domain |
Domain Context
CATH Clusters
| Superfamily | TruD, insertion domain |
| Functional Family | tRNA pseudouridine synthase D |
Enzyme Information
| 5.4.99.27 |
tRNA pseudouridine(13) synthase.
based on mapping to UniProt Q57261
tRNA uridine(13) = tRNA pseudouridine(13).
-!- Pseudouridine synthase PusS from Escherichia coli specifically acts on uridine(13) in tRNA. -!- The Pus7 protein from Saccharomyces cerevisiae is a multisite- multisubstrate pseudouridine synthase that is able to modify uridine(13) in several yeast tRNAs, uridine(35) in the pre-tRNA(Tyr), uridine(35) in U2 small nuclear RNA, and uridine(50) in 5S rRNA.
|
UniProtKB Entries (1)
| Q57261 |
TRUD_ECOLI
Escherichia coli K-12
TRNA pseudouridine synthase D
|
PDB Structure
| PDB | 1SB7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of the highly divergent pseudouridine synthase TruD reveals a circular permutation of a conserved fold.
Rna
|