CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.390 | Collagenase (Catalytic Domain) |
|
3.40.390.10 | Collagenase (Catalytic Domain) |
Domain Context
CATH Clusters
| Superfamily | Collagenase (Catalytic Domain) |
| Functional Family | Thimet oligopeptidase 1 |
Enzyme Information
| 3.4.24.15 |
Thimet oligopeptidase.
based on mapping to UniProt P52888
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.
-!- Thiol compounds activate at low concentrations. -!- Belongs to peptidase family M3. -!- Formerly EC 3.4.22.19 and EC 3.4.99.31.
|
UniProtKB Entries (1)
| P52888 |
THOP1_HUMAN
Homo sapiens
Thimet oligopeptidase
|
PDB Structure
| PDB | 1S4B |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization
J.Biol.Chem.
|
