CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | GDP-mannose 4,6-dehydratase |
Enzyme Information
| 4.2.1.47 |
GDP-mannose 4,6-dehydratase.
based on mapping to UniProt Q51366
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H(2)O.
-!- Forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-alpha-L-fucose. -!- In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalyzing the above reaction as well as the reaction catalyzed by EC 1.1.1.281.
|
UniProtKB Entries (1)
| Q51366 |
GM4D_PSEAE
Pseudomonas aeruginosa PAO1
GDP-mannose 4,6-dehydratase
|
PDB Structure
| PDB | 1RPN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of a tetrameric GDP-D-mannose 4,6-dehydratase from a bacterial GDP-D-rhamnose biosynthetic pathway.
Protein Sci.
|