CATH Domain 1rmu400

CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.80	Rhinovirus 14, subunit 4
	4.10.80.10	Picornavirus coat protein VP4

Domain Context

CATH Clusters

Superfamily	Picornavirus coat protein VP4
Functional Family

Enzyme Information

2.7.7.48	RNA-directed RNA polymerase. based on mapping to UniProt P03303 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.4.22.28	Picornain 3C. based on mapping to UniProt P03303 Selective cleavage of Gln-\|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. -!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
3.6.1.15	Nucleoside-triphosphate phosphatase. based on mapping to UniProt P03303 NTP + H(2)O = NDP + phosphate. -!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
3.4.22.29	Picornain 2A. based on mapping to UniProt P03303 Selective cleavage of Tyr-\|-Gly bond in the picornavirus polyprotein. -!- From entero- and rhinoviruses. -!- Smaller than the homologous virus picornain 3C. -!- Belongs to peptidase family C3.

UniProtKB Entries (1)

POLG_HRV14

Rhinovirus B14

Genome polyprotein

PDB Structure

PDB	1RMU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Homo
Primary Citation	Three-dimensional structures of drug-resistant mutants of human rhinovirus 14. Badger, J., Krishnaswamy, S., Kremer, M.J., Oliveira, M.A., Rossmann, M.G., Heinz, B.A., Rueckert, R.R., Dutko, F.J., McKinlay, M.A. J.Mol.Biol.