CATH Classification

Domain Context

CATH Clusters

Superfamily Urease, subunit C, domain 1
Functional Family Cytosine deaminase

Enzyme Information

3.5.4.1
Cytosine deaminase.
based on mapping to UniProt P25524
Cytosine + H(2)O = uracil + NH(3).
-!- Also acts on 5-methylcytosine.
3.5.4.-
In cyclic amidines.
based on mapping to UniProt P25524

UniProtKB Entries (1)

P25524
CODA_ECOLI
Escherichia coli K-12
Cytosine deaminase

PDB Structure

PDB 1R9X
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Mahan, S.D., Ireton, G.C., Knoeber, C., Stoddard, B.L., Black, M.E.
Protein Eng.Des.Sel.