CATH Domain 1r52A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.150	Chorismate synthase, AroC fold
	3.60.150.10	Chorismate synthase AroC

Domain Context

CATH Clusters

Superfamily	Chorismate synthase AroC
Functional Family

Enzyme Information

4.2.3.5

Chorismate synthase.

based on mapping to UniProt P28777

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.

-!- The reaction goes via a radical mechanism that involves reduced FMN and its semiquinone (FMNH.). -!- Shikimate is numbered so that the double-bond is between C-1 and C-2, but some earlier papers numbered the ring in the reverse direction. -!- Formerly EC 4.6.1.4.

UniProtKB Entries (1)

P28777

AROC_YEAST

Saccharomyces cerevisiae S288C

Chorismate synthase

PDB Structure

PDB	1R52
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the bifunctional chorismate synthase from Saccharomyces cerevisiae Quevillon-Cheruel, S., Leulliot, N., Meyer, P., Graille, M., Bremang, M., Blondeau, K., Sorel, I., Poupon, A., Janin, J., van Tilbeurgh, H. J.Biol.Chem.