CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A subunit), domain 1
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt Q9FBI2
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

Q7BQ98
STXB_SHIDY
Shigella dysenteriae
Shiga toxin subunit B

PDB Structure

PDB 1R4Q
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7.
Fraser, M.E., Fujinaga, M., Cherney, M.M., Melton-Celsa, A.R., Twiddy, E.M., O'Brien, A.D., James, M.N.G.
J.Biol.Chem.