CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.80 | Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module |
Domain Context
CATH Clusters
| Superfamily | Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module |
| Functional Family | NAD(P)H-flavin reductase |
Enzyme Information
| 1.5.1.41 |
Riboflavin reductase (NAD(P)H).
based on mapping to UniProt P0AEN1
Reduced riboflavin + NAD(P)(+) = riboflavin + NAD(P)H.
-!- Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. -!- Highest activity with riboflavin. -!- When NADH is used as acceptor, the enzyme can also utilize FMN and FAD as substrates, with lower activity than riboflavin. -!- When NADPH is used as acceptor, the enzyme has a very low activity with FMN and no activity with FAD. -!- Formerly EC 1.5.1.29 and EC 1.6.8.1.
|
UniProtKB Entries (1)
| P0AEN1 |
FRE_ECOLI
Escherichia coli K-12
NAD(P)H-flavin reductase
|
PDB Structure
| PDB | 1QFJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of NAD(P)H:flavin oxidoreductase from Escherichia coli.
Biochemistry
|
