CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.390 | Collagenase (Catalytic Domain) | |
3.40.390.10 | Collagenase (Catalytic Domain) |
Domain Context
CATH Clusters
Superfamily | Collagenase (Catalytic Domain) |
Functional Family | Lethal factor |
Enzyme Information
3.4.24.83 |
Anthrax lethal factor endopeptidase.
based on mapping to UniProt P15917
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.
-!- From the bacterium Bacilus anthracis that causes anthrax. -!- One of three proteins that are collectively termed anthrax toxin. -!- Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. -!- Belongs to peptidase family M34.
|
UniProtKB Entries (1)
P15917 |
LEF_BACAN
Bacillus anthracis
Lethal factor
|
PDB Structure
PDB | 1PWV |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Bacillus |
Primary Citation |
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol.
|