CATH Classification

Domain Context

CATH Clusters

Superfamily 2.70.40.10
Functional Family

Enzyme Information

3.5.4.30
dCTP deaminase (dUMP-forming).
based on mapping to UniProt Q57872
dCTP + 2 H(2)O = dUMP + diphosphate + NH(3).
-!- Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated. -!- While most bacteria require two enzymes to form dUMP from dCTP (EC 3.5.4.13 and EC 3.6.1.23), the archaeon Methanocaldococcus jannaschii uses a single enzyme to carry out both functions. -!- This enzyme can also act as a dUTP diphosphatase, but more slowly.

UniProtKB Entries (1)

Q57872
DCDB_METJA
Methanocaldococcus jannaschii DSM 2661
DCTP deaminase, dUMP-forming

PDB Structure

PDB 1PKH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for recognition and catalysis by the bifunctional dCTP deaminase and dUTPase from Methanococcus jannaschii
Huffman, J.L., Li, H., White, R.H., Tainer, J.A.
J.Mol.Biol.
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