CATH Classification
Domain Context
CATH Clusters
| Superfamily | N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 |
| Functional Family | 6-phosphogluconate dehydrogenase, decarboxylating |
Enzyme Information
| 1.1.1.44 |
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
based on mapping to UniProt P31072
6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.
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UniProtKB Entries (1)
| P31072 |
6PGD_TRYBB
Trypanosoma brucei brucei
6-phosphogluconate dehydrogenase, decarboxylating
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PDB Structure
| PDB | 1PGJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
A 2.8 A resolution structure of 6-phosphogluconate dehydrogenase from the protozoan parasite Trypanosoma brucei: comparison with the sheep enzyme accounts for differences in activity with coenzyme and substrate analogues.
J.Mol.Biol.
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