CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Pteridine reductase

Enzyme Information
Pteridine reductase.
based on mapping to UniProt P42556
5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 NADPH.
-!- The enzyme from Leishmania (both amastigote and promastigote forms) catalyzes the NADPH-dependent reduction of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. -!- It also catalyzes the reduction of 7,8-dihydropterins and 7,8- dihydrofolate to their tetrahydro forms. -!- In contrast to EC and EC, pteridine reductase will not catalyze the reduction of the quinonoid form of dihydrobiopterin. -!- The enzyme is specific for NADPH; no activity has been detected with NADH. -!- It also differs from EC in being specific for the B side of NADPH. -!- Formerly EC

UniProtKB Entries (1)

Leishmania tarentolae
Pteridine reductase 1

PDB Structure

PDB 1P33
External Links
Organism Escherichia
Primary Citation
Structure of pteridine reductase (PTR1) from Leishmania tarentolae.
Zhao, H., Bray, T., Ouellette, M., Zhao, M., Ferre, R.A., Matthews, D., Whiteley, J.M., Varughese, K.I.
Acta Crystallogr.,Sect.D