CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.630 | Aminopeptidase |
|
3.40.630.30 | Gcn5-related N-acetyltransferase (GNAT) |
Domain Context
CATH Clusters
| Superfamily | 3.40.630.30 |
| Functional Family | Mycothiol acetyltransferase |
Enzyme Information
| 2.3.1.189 |
Mycothiol synthase.
based on mapping to UniProt P9WJM7
Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.
-!- This enzyme catalyzes the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium. -!- The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs). -!- The enzyme has been purified from Mycobacterium tuberculosis H37Rv. -!- Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate.
|
UniProtKB Entries (1)
| P9WJM7 |
MSHD_MYCTU
Mycobacterium tuberculosis H37Rv
Mycothiol acetyltransferase
|
PDB Structure
| PDB | 1OZP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases.
Protein Sci.
|
