CATH Domain 1oxpA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1150	Aspartate Aminotransferase, domain 1
	3.90.1150.10	Aspartate Aminotransferase, domain 1

Domain Context

CATH Clusters

Superfamily	Aspartate Aminotransferase, domain 1
Functional Family	Aspartate aminotransferase

Enzyme Information

2.6.1.1	Aspartate transaminase. based on mapping to UniProt P00508 L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. -!- Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. -!- This activity can be formed from EC 2.6.1.57 by controlled proteolysis.
2.6.1.7	Kynurenine--oxoglutarate transaminase. based on mapping to UniProt P00508 L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. -!- Also acts on 3-hydroxykynurenine. -!- The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.

UniProtKB Entries (1)

AATM_CHICK

Gallus gallus

Aspartate aminotransferase, mitochondrial

PDB Structure

PDB	1OXP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase. Markovic-Housley, Z., Schirmer, T., Hohenester, E., Khomutov, A.R., Khomutov, R.M., Karpeisky, M.Y., Sandmeier, E., Christen, P., Jansonius, J.N. Eur.J.Biochem.