CATH Domain 1oguA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22

Cyclin-dependent kinase.

based on mapping to UniProt P24941

ATP + a protein = ADP + a phosphoprotein.

-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P20248

CCNA2_HUMAN

Homo sapiens

Cyclin-A2

PDB Structure

PDB	1OGU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Design of 2-Arylamino-4-Cyclohexyl Methyl-5-Nitroso-6-Aminopyrimidine Inhibitors of Cyclin-Dependent Kinases 1 and 2 Sayle, K.L., Bentley, J., Boyle, F.T., Calvert, A.H., Cheng, Y., Curtin, N.J., Endicott, J.A., Golding, B.T., Hardcastle, I.R., Jewsbury, P., Mesguiche, V., Newell, D.R., Noble, M.E.M., Parsons, R.J., Pratt, D.J., Wang, L.Z., Griffin, R.J. Bioorg.Med.Chem.Lett.