CATH Classification

Domain Context

CATH Clusters

Superfamily Helix hairpin bin
Functional Family 23S rRNA (guanine(2535)-N(1))-methyltransferase

Enzyme Information

2.1.1.209
23S rRNA (guanine(2535)-N(1))-methyltransferase.
based on mapping to UniProt Q9F5K5
S-adenosyl-L-methionine + guanine(2535) in 23S rRNA = S-adenosyl-L- homocysteine + N(1)-methylguanine(2535) in 23S rRNA.
-!- Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. -!- To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (guanine(2535)-N(1))- methyltransferase and EC 2.1.1.208 whose actions confer avilamycin resistance to the RNA.

UniProtKB Entries (1)

Q9F5K5
AVRA_STRVR
Streptomyces viridochromogenes
23S rRNA (guanine(2535)-N(1))-methyltransferase

PDB Structure

PDB 1O9H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Avilamycin Resistance-Conferring Methyltransferase Avira from Streptomyces Viridochromogenes
Mosbacher, T.G., Bechthold, A., Schulz, G.E.
J.Mol.Biol.
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