CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.287 | Helix Hairpins | |
1.10.287.540 | Helix hairpin bin |
Domain Context
CATH Clusters
Superfamily | Helix hairpin bin |
Functional Family | 23S rRNA (guanine(2535)-N(1))-methyltransferase |
Enzyme Information
2.1.1.209 |
23S rRNA (guanine(2535)-N(1))-methyltransferase.
based on mapping to UniProt Q9F5K5
S-adenosyl-L-methionine + guanine(2535) in 23S rRNA = S-adenosyl-L- homocysteine + N(1)-methylguanine(2535) in 23S rRNA.
-!- Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. -!- To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (guanine(2535)-N(1))- methyltransferase and EC 2.1.1.208 whose actions confer avilamycin resistance to the RNA.
|
UniProtKB Entries (1)
Q9F5K5 |
AVRA_STRVR
Streptomyces viridochromogenes
23S rRNA (guanine(2535)-N(1))-methyltransferase
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PDB Structure
PDB | 1O9H |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal Structure of the Avilamycin Resistance-Conferring Methyltransferase Avira from Streptomyces Viridochromogenes
J.Mol.Biol.
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