CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 |
Enzyme Information
| 2.8.2.8 |
[Heparan sulfate]-glucosamine N-sulfotransferase.
based on mapping to UniProt P52848
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine.
-!- The enzyme also catalyzes the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent. -!- Formerly EC 2.8.2.12.
|
| 2.8.2.- |
Sulfotransferases.
based on mapping to UniProt P52848
|
| 3.-.-.- |
Hydrolases.
based on mapping to UniProt P52848
|
UniProtKB Entries (1)
| P52848 |
NDST1_HUMAN
Homo sapiens
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
|
PDB Structure
| PDB | 1NST |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1.
J.Biol.Chem.
|
