CATH Domain 1nl6A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38

Cathepsin K.

based on mapping to UniProt P43235

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P43235

CATK_HUMAN

Homo sapiens

Cathepsin K

PDB Structure

PDB	1NL6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Azepanone-based inhibitors of human and rat cathepsin K Marquis, R.W., Ru, Y., LoCastro, S.M., Zeng, J., Yamashita, D.S., Oh, H.J., Erhard, K.F., Davis, L.D., Tomaszek, T.A., Tew, D., Salyers, K., Proksch, J., Ward, K., Smith, B., Levy, M., Cummings, M.D., Haltiwanger, R.C., Trescher, G., Wang, B., Hemling, M.E., Quinn, C.J., Cheng, H.-Y., Lin, F., Smith, W.W., Janson, C.A., Zhao, B., McQueney, M.S., D'Alessio, K., Lee, C.P., Marzulli, A., A Dodds, R., Blake, S., Hwang, S.M., James, I.E., Gress, C.J., Bradley, B.R., Lark, M.W., Gowen, M., Veber, D.F. J.Med.Chem.