CATH Domain 1nd4B02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1200	Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2
	3.90.1200.10	Aminoglycoside phosphotransferase (APH), C-terminal lobe

Domain Context

CATH Clusters

Superfamily	3.90.1200.10
Functional Family

Enzyme Information

2.7.1.95

Kanamycin kinase.

based on mapping to UniProt P00552

ATP + kanamycin = ADP + kanamycin 3'-phosphate.

-!- Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. -!- An enzyme from Pseudomonas aeruginosa also acts on butirosin.

UniProtKB Entries (1)

P00552

KKA2_KLEPN

Klebsiella pneumoniae

Aminoglycoside 3'-phosphotransferase

PDB Structure

PDB	1ND4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance Nurizzo, D., Shewry, S.C., Perlin, M.H., Brown, S.A., Dholakia, J.N., Fuchs, R.L., Deva, T., Baker, E.N., Smith, C.A. J.Mol.Biol.