CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family | NADPH-ferredoxin reductase FprA |
Enzyme Information
| 1.18.1.2 |
Ferredoxin--NADP(+) reductase.
based on mapping to UniProt P9WIQ3
2 reduced ferredoxin + NADP(+) + H(+) = 2 oxidized ferredoxin + NADPH.
-!- In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe- 2S] ferredoxins, but in other bacteria it can also reduce bacterial 2[4Fe-4S] ferredoxins and flavodoxin. -!- Formerly EC 1.6.7.1 and EC 1.6.99.4.
|
UniProtKB Entries (1)
| P9WIQ3 |
FPRA_MYCTU
Mycobacterium tuberculosis H37Rv
NADPH-ferredoxin reductase FprA
|
PDB Structure
| PDB | 1LQU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase.
Biochemistry
|
