CATH Domain 1llzA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	Ferredoxin-dependent glutamate synthase, chloroplastic

Enzyme Information

1.4.7.1

Glutamate synthase (ferredoxin).

based on mapping to UniProt P55038

2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H(+).

-!- The protein is composed of two domains, one hydrolyzing L-glutamine to NH(3) and L-glutamate (cf. EC 3.5.1.2), the other combining the produced NH(3) with 2-oxoglutarate to produce a second molecule of L-glutamate. -!- The NH(3) is channeled through a 24 A channel in the active protein. -!- No hydrolysis of glutamine takes place without ferredoxin and 2-oxoglutarate being bound to the protein.

UniProtKB Entries (1)

P55038

GLTS_SYNY3

Synechocystis sp. PCC 6803 substr. Kazusa

Ferredoxin-dependent glutamate synthase 2

PDB Structure

PDB	1LLZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural studies on the synchronization of catalytic centers in glutamate synthase van den Heuvel, R.H., Ferrari, D., Bossi, R.T., Ravasio, S., Curti, B., Vanoni, M.A., Florencio, F.J., Mattevi, A. J.BIOL.CHEM.