CATH Domain 1lbkA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1050	Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
	1.20.1050.10

Domain Context

CATH Clusters

Superfamily	1.20.1050.10
Functional Family	Glutathione S-transferase P

Enzyme Information

2.5.1.18

Glutathione transferase.

based on mapping to UniProt P09211

RX + glutathione = HX + R-S-glutathione.

-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P09211

GSTP1_HUMAN

Homo sapiens

Glutathione S-transferase P

PDB Structure

PDB	1LBK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences. Micaloni, C., Kong, G.K.W., Mazzetti, A.P., Nuccetelli, M., Antonini, G., Stella, L., McKinstry, W.J., Polekhina, G., Rossjohn, J., Federici, G., Ricci, G., Parker, M.W., Lo Bello, M. J.Mol.Biol.