CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.19 | Aconitase; domain 4 |
|
3.20.19.10 | Aconitase, domain 4 |
Domain Context
CATH Clusters
| Superfamily | Aconitase, domain 4 |
| Functional Family | Aconitate hydratase B |
Enzyme Information
| 4.2.1.99 |
2-methylisocitrate dehydratase.
based on mapping to UniProt P36683
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3- tricarboxylate + H(2)O.
-!- The enzyme from the fungus Yarrowia lipolytica does not act on isocitrate.
|
| 4.2.1.3 |
Aconitate hydratase.
based on mapping to UniProt P36683
Citrate = isocitrate.
-!- Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. -!- The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. -!- Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate. -!- Formerly EC 4.2.1.4.
|
UniProtKB Entries (1)
| P36683 |
ACNB_ECOLI
Escherichia coli K-12
Aconitate hydratase B
|
PDB Structure
| PDB | 1L5J |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
E. coli aconitase B structure reveals a HEAT-like domain with implications for protein-protein recognition.
Nat.Struct.Biol.
|
