CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.630.30
Functional Family Serotonin N-acetyltransferase

Enzyme Information

2.3.1.87
Aralkylamine N-acetyltransferase.
based on mapping to UniProt Q29495
Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine.
-!- Narrow specificity toward 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. -!- This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4). -!- Differs from EC 2.3.1.5.

UniProtKB Entries (1)

Q29495
SNAT_SHEEP
Ovis aries
Serotonin N-acetyltransferase

PDB Structure

PDB 1L0C
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Investigation of the roles of catalytic residues in serotonin N-acetyltransferase.
Scheibner, K.A., De Angelis, J., Burley, S.K., Cole, P.A.
J.Biol.Chem.
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