CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.630 | Aminopeptidase | |
3.40.630.30 | Gcn5-related N-acetyltransferase (GNAT) |
Domain Context
CATH Clusters
Superfamily | 3.40.630.30 |
Functional Family | Serotonin N-acetyltransferase |
Enzyme Information
2.3.1.87 |
Aralkylamine N-acetyltransferase.
based on mapping to UniProt Q29495
Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine.
-!- Narrow specificity toward 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. -!- This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4). -!- Differs from EC 2.3.1.5.
|
UniProtKB Entries (1)
Q29495 |
SNAT_SHEEP
Ovis aries
Serotonin N-acetyltransferase
|
PDB Structure
PDB | 1L0C |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Investigation of the roles of catalytic residues in serotonin N-acetyltransferase.
J.Biol.Chem.
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