CATH Domain 1kpgA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family	Cyclopropane mycolic acid synthase 1

Enzyme Information

2.1.1.79

Cyclopropane-fatty-acyl-phospholipid synthase.

based on mapping to UniProt P9WPB7

S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl- L-homocysteine + phospholipid cyclopropane fatty acid.

-!- Adds a methylene group across the 9,10 position of a Delta(9)- olefinic acyl chain in phosphatidylethanolamine or, more slowly, phosphatidylglycerol or phosphatidylinositol forming a cyclopropane derivative (cf. EC 2.1.1.16).

UniProtKB Entries (1)

P9WPB7

CMAS1_MYCTU

Mycobacterium tuberculosis H37Rv

Cyclopropane mycolic acid synthase 1

PDB Structure

PDB	1KPG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis Huang, C.-C., Smith, C.V., Glickman, M.S., Jacobs Jr., W.R., Sacchettini, J.C. J.Biol.Chem.