CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Glutathione-independent formaldehyde dehydrogenase |
Enzyme Information
| 1.2.1.46 |
Formaldehyde dehydrogenase.
based on mapping to UniProt P46154
Formaldehyde + NAD(+) + H(2)O = formate + NADH.
|
| 1.2.98.1 |
Formaldehyde dismutase.
based on mapping to UniProt P46154
2 formaldehyde + H(2)O = formate + methanol.
-!- Enzyme-bound NADPH formed by oxidation of formaldehyde to formate is oxidized back to NADP(+) by reaction with a second formaldehyde, yielding methanol. -!- The enzyme from Mycobacterium sp. DSM 3803 also catalyzes the reactions of EC 1.1.99.36 and EC 1.1.99.37. -!- Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors. -!- Formerly EC 1.2.99.4.
|
UniProtKB Entries (1)
| P46154 |
FADH_PSEPU
Pseudomonas putida
Glutathione-independent formaldehyde dehydrogenase
|
PDB Structure
| PDB | 1KOL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structure of Formaldehyde Dehydrogenase from Pseudomonas putida: the Structural Origin of the Tightly Bound Cofactor in Nicotinoprotein Dehydrogenases
J.mol.biol.
|