CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family Cruciform cutting endonuclease

Enzyme Information

3.1.22.4
Crossover junction endodeoxyribonuclease.
based on mapping to UniProt Q10423
Endonucleolytic cleavage at a junction such as a reciprocal single- stranded crossover between two homologous DNA duplexes (Holliday junction).
-!- The enzyme from Saccharomyces cerevisiae has no endonuclease or exonuclease activity on single-stranded or double-stranded DNA molecules that do not contain Holliday junctions.

UniProtKB Entries (1)

Q10423
CCE1_SCHPO
Schizosaccharomyces pombe 972h-
Cruciform cutting endonuclease 1, mitochondrial

PDB Structure

PDB 1KCF
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2.
Ceschini, S., Keeley, A., McAlister, M.S., Oram, M., Phelan, J., Pearl, L.H., Tsaneva, I.R., Barrett, T.E.
EMBO J.