CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.5 | Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
|
1.20.5.1300 |
Domain Context
CATH Clusters
| Superfamily | 1.20.5.1300 |
| Functional Family | Histidine biosynthesis trifunctional protein |
Enzyme Information
| 1.1.1.23 |
Histidinol dehydrogenase.
based on mapping to UniProt P06988
L-histidinol + H(2)O + 2 NAD(+) = L-histidine + 2 NADH.
-!- Also oxidizes L-histidinal. -!- The Neurospora enzyme also catalyzes the reactions of EC 3.5.4.19 and EC 3.6.1.31.
|
UniProtKB Entries (1)
| P06988 |
HISX_ECOLI
Escherichia coli K-12
Histidinol dehydrogenase
|
PDB Structure
| PDB | 1KAH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase.
Proc.Natl.Acad.Sci.USA
|