CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | Polyamine aminopropyltransferase |
Enzyme Information
| 2.5.1.16 |
Spermidine synthase.
based on mapping to UniProt Q9WZC2
S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl- 5'-thioadenosine + spermidine.
-!- The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor. -!- The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant toward other amine acceptors, such as spermidine and cadaverine. -!- Cf. EC 2.5.1.22 and EC 2.5.1.23.
|
UniProtKB Entries (1)
| Q9WZC2 |
SPEE_THEMA
Thermotoga maritima MSB8
Polyamine aminopropyltransferase
|
PDB Structure
| PDB | 1JQ3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor.
Nat.Struct.Biol.
|
