CATH Domain 1jheA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.109	Umud Fragment, subunit A
	2.10.109.10	Umud Fragment, subunit A

Domain Context

CATH Clusters

Superfamily	Umud Fragment, subunit A
Functional Family	LexA repressor

Enzyme Information

3.4.21.88

Repressor LexA.

based on mapping to UniProt P0A7C2

Hydrolysis of Ala-|-Gly bond in repressor LexA.

-!- In the presence of single-stranded DNA, the RecA protein interacts with LexA causing an autocatalytic cleavage which disrupts the DNA- binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. -!- The activity was previously attributed to the RecA protein (formerly EC 3.4.99.37). -!- Belongs to peptidase family S24.

UniProtKB Entries (1)

P0A7C2

LEXA_ECOLI

Escherichia coli K-12

LexA repressor

PDB Structure

PDB	1JHE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of LexA: a conformational switch for regulation of self-cleavage. Luo, Y., Pfuetzner, R.A., Mosimann, S., Paetzel, M., Frey, E.A., Cherney, M., Kim, B., Little, J.W., Strynadka, N.C. Cell(Cambridge,Mass.)