CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Polyamine aminopropyltransferase

Enzyme Information

2.5.1.16
Spermidine synthase.
based on mapping to UniProt P70998
S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl- 5'-thioadenosine + spermidine.
-!- The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor. -!- The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant toward other amine acceptors, such as spermidine and cadaverine. -!- Cf. EC 2.5.1.22 and EC 2.5.1.23.

UniProtKB Entries (1)

P70998
SPEE_BACSU
Bacillus subtilis subsp. subtilis str. 168
Polyamine aminopropyltransferase

PDB Structure

PDB 1IY9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of spermidine synthase
Tan, A.Y., Smith, P.C., Shen, J., Xiao, R., Acton, T., Rost, B., Montelione, G., Hunt, J.F.
To be Published
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