CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.200 |
Domain Context
CATH Clusters
| Superfamily | 2.60.120.200 |
| Functional Family | Exotoxin A |
Enzyme Information
| 2.4.2.36 |
NAD(+)--diphthamide ADP-ribosyltransferase.
based on mapping to UniProt P11439
NAD(+) + diphthamide-[translation elongation factor 2] = nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2].
-!- Dihtheria toxin and some other bacterial toxins catalyze this reaction, which inactivates translation elongation factor 2 (EF2). -!- The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. -!- Cf. EC 2.4.2.31. -!- The relevant histidine of EF2 is His(715) in mammals, His(699) in yeast and His(600) in Pyrococcus horikoshii.
|
UniProtKB Entries (1)
| P11439 |
TOXA_PSEAE
Pseudomonas aeruginosa PAO1
Exotoxin A
|
PDB Structure
| PDB | 1IKQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Refined Crystallographic Structure of Pseudomonas aeruginosa Exotoxin A
and its Implications for the Molecular Mechanism of Toxicity
J.Mol.Biol.
|