CATH Classification

Domain Context

CATH Clusters

Superfamily DHBP synthase
Functional Family 3,4-dihydroxy-2-butanone 4-phosphate synthase

Enzyme Information

4.1.99.12
3,4-dihydroxy-2-butanone-4-phosphate synthase.
based on mapping to UniProt P0A7J0
D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.
-!- The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5. -!- The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin.

UniProtKB Entries (1)

P0A7J0
RIBB_ECOLI
Escherichia coli K-12
3,4-dihydroxy-2-butanone 4-phosphate synthase

PDB Structure

PDB 1IEZ
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site.
Kelly, M.J., Ball, L.J., Krieger, C., Yu, Y., Fischer, M., Schiffmann, S., Schmieder, P., Kuhne, R., Bermel, W., Bacher, A., Richter, G., Oschkinat, H.
Proc.Natl.Acad.Sci.USA
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