CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.880 | Class I glutamine amidotransferase (GATase) domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.880 |
| Functional Family | Anthranilate phosphoribosyltransferase |
Enzyme Information
| 2.4.2.18 |
Anthranilate phosphoribosyltransferase.
based on mapping to UniProt P00905
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).
|
| 4.1.3.27 |
Anthranilate synthase.
based on mapping to UniProt P00905
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.1.48, EC 4.2.1.20 and EC 5.3.1.24). -!- The native enzyme in the complex with uses either glutamine or (less efficiently) NH(3). -!- The enzyme separated from the complex uses NH(3) only.
|
UniProtKB Entries (1)
| P00898 |
TRPE_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Anthranilate synthase component 1
|
PDB Structure
| PDB | 1I1Q |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of the cooperative allosteric anthranilate synthase from Salmonella typhimurium.
Nat.Struct.Biol.
|
