CATH Classification
Level | CATH Code | Description |
---|---|---|
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2 | Mainly Beta |
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2.30 | Roll |
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2.30.30 | SH3 type barrels. |
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2.30.30.100 |
Domain Context
CATH Clusters
Superfamily | 2.30.30.100 |
Functional Family | Bifunctional ligase/repressor BirA |
Enzyme Information
6.3.4.15 |
Biotin--[biotin carboxyl-carrier protein] ligase.
based on mapping to UniProt P06709
ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N(6)-biotinyl-L-lysine.
-!- The enzyme biotinylates a biotin carboxyl-carrier protein that is part of an acetyl-CoA carboxylase complex, enabling its subsequent carboxylation by EC 6.3.4.14. -!- The carboxyl group is eventually transferred to acetyl-CoA by EC 2.1.3.15. -!- In some organisms the carrier protein is part of EC 6.4.1.2.
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UniProtKB Entries (1)
P06709 |
BIRA_ECOLI
Escherichia coli K-12
Bifunctional ligase/repressor BirA
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PDB Structure
PDB | 1HXD |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Corepressor-induced organization and assembly of the biotin repressor: a model for allosteric activation of a transcriptional regulator.
Proc.Natl.Acad.Sci.USA
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