CATH Classification
Domain Context
CATH Clusters
| Superfamily | 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2 |
| Functional Family | 3-hydroxy-3-methylglutaryl coenzyme A reductase |
Enzyme Information
| 1.1.1.34 |
Hydroxymethylglutaryl-CoA reductase (NADPH).
based on mapping to UniProt P04035
(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
-!- The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.
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UniProtKB Entries (1)
| P04035 |
HMDH_HUMAN
Homo sapiens
3-hydroxy-3-methylglutaryl-coenzyme A reductase
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PDB Structure
| PDB | 1HWL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural mechanism for statin inhibition of HMG-CoA reductase.
Science
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